We have discussed the importance of T cell composition for lymphoma / solid tumor patients and the use of car T cell products. Importantly, it is possible to indirectly regulate T cell composition by using optimized extension protocols. Schmueck henneresse et al. It is reported that IL2 (including yescarta) is widely used in clinical car-t proliferation ® And kymriah ®） In contrast, the combina···

Another high-quality project started, and Wujiang Development Zone acceleratedThis morning (September 29), Suzhou Fangde Menda new drug development Co., Ltd. (hereinafter referred to as "Fangde Menda") ）The new thiscar-t product R & D and clinical production base project was started in Wujiang development zone. This marks a new page for Wujiang Development Zone to fully promote ···

NO.01IntroductionDespite the remarkable progress of car-t cell therapy, more than 50% of patients treated with chimeric antigen receptor T cells targeting CD19 (Car19) still have disease progression. Of the 16 patients with large B-cell lymphoma (lbcl) who progressed after Car19 treatment, 10 had no CD19 or low CD19. Decreased cell surface CD19 density is associated with disease progression.To pre···

Adoptive immunotherapy is a revolutionary treatment method in hematology. It expresses and synthesizes chimeric antigen receptor (car) in T cells through genetic engineering. Car-t cells targeting CD19 antigen in B-cell leukemia and lymphoma have been clinically recognized and become a "conventional" treatment method implemented by cancer centers all over the world.Car structure consists···