② Promote efficient T cell transduction at low viral dose (MOI = 1)
③ Selective expansion of car + CD8 + cells
④ Without separating magnetic beads, the production process is simplified and the safety is increased
⑤ It gets rid of the dependence and use restrictions on the import of magnetic bead reagents
Comparison between fandemenda T cell activator and similar products
Lentivirus vector is the most mature, safest and widely used T cell transgenic tool. Its yield and quality have always been one of the bottlenecks restricting the preparation, production and clinical effect of cart cells. After two years of technical breakthrough, Fangde Menda team has realized the following bottom process innovation in standardized and large-scale lentivirus production.
(1) Serum free production of clinical grade lentivirus vector;
(2) The dosage of clinical lentivirus vector meeting 100-200 people can be obtained by single batch production.
Lentivirus production flow chart: